THE EFFECTIVENESS OF PHARMACOLOGIC TREATMENT FOR REGRESSION OF CLINICAL SYMPTOMS AND INDICATIONS FOR SURGICAL TREATMENT OF CHRONIC NASOPHARYNGITIS ASSOCIATED WITH EPSTEIN-BARR VIRUS

Chronic nasopharyngitis (CNP) associated with Epstein-Barr virus (EBV) is etiopathogenetically based on the virus-induced chronic inflammation of pharyngeal tonsil. Studies using immunological methods have shown that EBV involved in hypertrophy lymphoid tissue pharynx children and adolescents, since tonsil site primary infection persistence virus. The surgery does not often resolve problem 19-26% patients. Therefore, there are many questions regarding choice adequate therapy would show its effectiveness.
 Objective: to evaluate effect treatment CNP phytoneering extract BNO 1030 dynamics main clinical symptoms indications for surgery.
 Material methods. A total 108 outpatients divided into two groups: experimental (n-54) control (n-54). Verification was carried out according ELISA reaction profile: IgM-VCA/IgG-EA/IgG-EBNA. All patients were prescribed a background group additionally received 1030. evaluation effectiveness analysis symptoms, degree tonsil, existence surgical treatment. Symptom assessment performed V1 (day 0), V2 51), V3 101), V4 141). Indications intervention (adenotomy) determined together patient's parents.
 Results. Clinical include runny or stuffy nose, postnasal drip, nasal voice, posterior cervical lymphadenopathy. Symptoms rated, average, from 0 3 points 4-point MSS scale corresponds moderate course CNP. At V1, both groups showed comparable symptom scores.
 use addition proved efficacy. V4, group, observed clinically significant decrease severity congestion, nasality, enlarged lymph nodes (p<0.05). There insignificant difference between discharge drip at all visits (р> 0,05).
 indicators before operation. differences After eliminating operated patients, no (p> 0.05). need decreased group. 14.8% adenotomy rate observed: 53.7% 38.9% Conservative prolonged 61.1% 46.3% group.
 No patient developed side effects.
 Conclusions: pharmacologic has improved reduced